Treatment with monoclonal antibodies to ICAM-1 and LFA-1 in rat heart allograft rejection
نویسندگان
چکیده
منابع مشابه
Suppression of experimental uveitis with monoclonal antibodies to ICAM-1 and LFA-1.
PURPOSE Intercellular adhesion molecule-1 (ICAM-1), which is one of the ligands for lymphocyte function associated antigen-1 (LFA-1), plays an important role in immune responses. To examine whether ICAM-1 and LFA-1 are involved in the pathogenesis of experimental autoimmune uveoretinitis (EAU), the authors investigated the therapeutic effect of anti-ICAM-1 monoclonal antibody (mAb) 1A29 and ant...
متن کاملEffect of LFA-1 and ICAM-1 antibody treatment on murine corneal allograft survival.
PURPOSE To examine the effect of anti-LFA-1 and anti-ICAM-1 antibody treatment on orthotopic corneal graft survival in a mouse model. METHODS Anti-LFA-1 and anti-ICAM-1 antibodies were administered intraperitoneally before and shortly after orthotopic corneal transplantation. Grafts were observed by biomicroscopy, and survival times were determined. Cytotoxic T lymphocyte (CTL) and delayed-ty...
متن کاملICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway
The interaction of lymphocyte function-associated antigen-1 (LFA-1) with its ligands mediates multiple cell adhesion processes of capital importance during immune responses. We have obtained three anti-ICAM-3 mAbs which recognize two different epitopes (A and B) on the intercellular adhesion molecule-3 (ICAM-3) as demonstrated by sequential immunoprecipitation and cross-competitive mAb-binding ...
متن کاملRole of ICAM-1 in chronic hepatic allograft rejection in the rat.
The pathogenesis of hepatic allograft rejection remains unclear. We aimed to clarify the early role of intercellular adhesion molecule-1 (ICAM-1)-mediated cell recruitment in chronic hepatic rejection. Liver transplantation was performed from Lewis to Lewis rats (isograft controls) and from Lewis to Brown Norway rats (allograft rejection group). The allografted rats were treated with either ICA...
متن کاملDifferential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation.
Cellular adhesion through the beta2 integrin lymphocyte function-associated Ag (LFA)-1 is a complex event involving activation, ligand binding, and cell shape changes that ultimately result in enhanced adhesion. In this report we define requirements for ligand binding and post receptor signaling by comparing two mechanisms of activation of LFA-1: 1) inside-out signaling and 2) direct activation...
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ژورنال
عنوان ژورنال: Transplant International
سال: 1997
ISSN: 0934-0874,1432-2277
DOI: 10.1111/j.1432-2277.1997.tb00557.x